Blue Brain Project in Artificial Intelligence: Just like `` from hand-drawn maps to Google Earth '', the `` Blue Brain Cell Atlas...
Blue Brain Project in Artificial Intelligence:
Just like `` from hand-drawn maps to Google Earth '', the `` Blue Brain Cell Atlas '' enables anyone to visualize each area of the mouse brain on a cell-by-cell basis.
The first digital 3D map of each cell in the mouse brain provided neuroscientists with previously unavailable information about the major cell types, numbers, and locations of all 737 brain regions. It is published by EPFL's Blue Brain Project and is published in Frontiers by Neuroinformatics, which integrates data from thousands of whole brain tissue stains into a comprehensive, interactive and dynamic online resource that you can update with new discoveries. This groundbreaking digital atlas can be used for analysis and further modeling of specific brain regions and is an important step in fully simulating rodent brains.
"Despite extensive research over the past century, only 4% of the mouse brain area provided cell numbers, and these estimates often differ by as much as three times," said Henry, the founder and head of the Blue Brain Project. "The blue brain cell map addresses this problem by providing the best estimate of the smallest known area of the mouse brain."
Csaba Erö's Lead Author And Creator Explained:
"Understanding circuit components and how they are arranged is also an important starting point for brain modeling, just as demographic data is critical to building a national model."
Previous Blue brain atlases are consist of brain slice image stacks. Some can show the exact cell location of the entire brain, while others can show specific cell types, but none can convert these valuable data into the number and location of all cells in the brain in the form of a digital navigable atlas.
This revolutionary step took five years to carefully collect and integrate thousands of brain tissue stains. Erö and his colleagues mainly rely on all imaging data obtained from the Allen Institute of Brain Science and combine it with a large number of other anatomical studies to calculate and verify the main cell type, number, and location of each region of the brain Include all areas where cell data has never been obtained before.
"Our cell atlas is like a hand-drawn map, a digitized version of satellite images depicting cities and geographic features, enabling us to navigate the brain through Google Earth," said Mark's Blue Brain Manager. -Oliver Gewaltig. It's 3D, high resolution, searchable, navigable, annotated and easy to use, filling a huge gap in our knowledge of 96% mouse brain regions. ''
Blue Brain Cell Atlas is available online for free, and users can view all 737 brain regions and the cells they contain, and download the regions and their numbers and locations. It distinguishes between excitatory, inhibitory, and some other types of neurons, as well as the main types of non-neuronal cells (called glial cells), which separate and protect neurons. This data is important for researchers trying to understand the structure and function of different brain regions or for modeling the function of specific brain regions.
Gewaltig added: "It's also a great teaching tool: you can choose to show only areas of interest and navigate to the proportion of individual cells in those areas that are color-coded by their morphological type."
The Blue Brain Cell Atlas is also the first dynamic brain atlas, allowing researchers to use any new data to promote and improve the atlas. "We can now work together to move towards the basic facts inside the rat's brain," Markram explained.
Supercomputer-based reconstruction and simulation built by Blue Brain provides a whole new way to understand the multi-layered structure and function of the brain. For more information, visit bluebrain.epfl.ch
Its main tasks are three tasks: teaching, research and technology transfer. EPFL works with a wide network of partners, including other universities and polytechnics, developing and emerging countries, middle schools, and colleges, industry and economics, political circles and the public, to make a real impact on society.
Previous Blue brain atlases are consist of brain slice image stacks. Some can show the exact cell location of the entire brain, while others can show specific cell types, but none can convert these valuable data into the number and location of all cells in the brain in the form of a digital navigable atlas.
This revolutionary step took five years to carefully collect and integrate thousands of brain tissue stains. Erö and his colleagues mainly rely on all imaging data obtained from the Allen Institute of Brain Science and combine it with a large number of other anatomical studies to calculate and verify the main cell type, number, and location of each region of the brain Include all areas where cell data has never been obtained before.
"Our cell atlas is like a hand-drawn map, a digitized version of satellite images depicting cities and geographic features, enabling us to navigate the brain through Google Earth," said Mark's Blue Brain Manager. -Oliver Gewaltig. It's 3D, high resolution, searchable, navigable, annotated and easy to use, filling a huge gap in our knowledge of 96% mouse brain regions. ''
Blue Brain Cell Atlas is available online for free, and users can view all 737 brain regions and the cells they contain, and download the regions and their numbers and locations. It distinguishes between excitatory, inhibitory, and some other types of neurons, as well as the main types of non-neuronal cells (called glial cells), which separate and protect neurons. This data is important for researchers trying to understand the structure and function of different brain regions or for modeling the function of specific brain regions.
Gewaltig added: "It's also a great teaching tool: you can choose to show only areas of interest and navigate to the proportion of individual cells in those areas that are color-coded by their morphological type."
The Blue Brain Cell Atlas is also the first dynamic brain atlas, allowing researchers to use any new data to promote and improve the atlas. "We can now work together to move towards the basic facts inside the rat's brain," Markram explained.
About The Blue Brain Project of The EPFL:
EPFL's "Blue Brain Project" is a Swiss brain project founded and directed by Professor Henry Maclam. Its purpose is to establish accurate, biologically detailed digital reconstruction and simulation of rodents and even human brains.Supercomputer-based reconstruction and simulation built by Blue Brain provides a whole new way to understand the multi-layered structure and function of the brain. For more information, visit bluebrain.epfl.ch
Contributors And Funding:
This work was funded by the EPFL Blue Brain Project Fund and the ETH Board. This work is an in-kind contribution to the European Union's Seventh Framework Programme (FP7 / 2007-2013) under Grant Agreement No. 7. 604102 (Human Brain Project) and EU Horizon 2020 Research and Innovation Framework Program (Grant No. 270270) (Human Brain Project SGA1).About EPFL:
EPFL is one of the two Swiss Federal Institutes of Technology in Lausanne. It is the most international technical university in Europe, with students, professors and staff from more than 120 countries. EPFL is a dynamic environment open to Switzerland and the world.Its main tasks are three tasks: teaching, research and technology transfer. EPFL works with a wide network of partners, including other universities and polytechnics, developing and emerging countries, middle schools, and colleges, industry and economics, political circles and the public, to make a real impact on society.
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